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In the Fight Against Viral Infection, Spelling Counts

Now, scientists have found that a key similarity between our genes and those of many viruses -- a way of spelling out the genetic code -- has likely allowed viruses to evade our cellular defenses. Paul Bieniasz, a Rockefeller professor and Howard Hughes Medical Institute Investigator who led the work,

Seemingly Acute Viral Infections Can Persist

New findings from the University of Pennsylvania suggest a mechanism that may explain how viruses can linger. Products of viral infection called defective viral genomes, DVGs for short, which have been known to be involved in triggering an immune response, can also kick off a molecular pathway that keeps infected

PET imaging tracks Zika virus infection, disease progression in mouse model

Small-animal imaging has become an important research tool for preclinical studies of infectious diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). "Traditional methods of infectious disease research using animal models have provided limited information about disease progression until the

‘Missing Link’ Explains How Viruses Trigger Immunity

The research team demonstrated a protein called SIDT2 was crucial for cells to detect viral components in their environment, and initiate an immune response to reduce the virus' spread. As well as being an important part of the intricate 'arms race' between viruses and our immune system, the finding could inform

Researcher Identifies a New Way to Treat HIV

I-Chueh Huang has spent 13 years researching how the human immune system controls viral infections. His lab recently pinpointed a protein variant that can be targeted to prevent the human immunodeficiency virus from harming HIV-positive individuals. "Most HIV drugs target the virus," said Huang, assistant professor of molecular microbiology and immunology

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