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PET imaging tracks Zika virus infection, disease progression in mouse model

Small-animal imaging has become an important research tool for preclinical studies of infectious diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). "Traditional methods of infectious disease research using animal models have provided limited information about disease progression until the

‘Missing Link’ Explains How Viruses Trigger Immunity

The research team demonstrated a protein called SIDT2 was crucial for cells to detect viral components in their environment, and initiate an immune response to reduce the virus' spread. As well as being an important part of the intricate 'arms race' between viruses and our immune system, the finding could inform

Researcher Identifies a New Way to Treat HIV

I-Chueh Huang has spent 13 years researching how the human immune system controls viral infections. His lab recently pinpointed a protein variant that can be targeted to prevent the human immunodeficiency virus from harming HIV-positive individuals. "Most HIV drugs target the virus," said Huang, assistant professor of molecular microbiology and immunology

Scientists Reel in Structure of Salmon Virus

The Rice lab of structural biologist Yizhi Jane Tao produced the first full-length structure of the matrix protein found in an orthomyxovirus that causes anemia in Atlantic salmon. Because the protein's structure and function are so similar to what has been found so far in influenza viruses, Tao expects they

Researchers Develop First Chikungunya Vaccine From Virus That Does not Affect People

"This vaccine offers efficient, safe and affordable protection against chikungunya and builds the foundation for using viruses that only infect insects to develop vaccines against other insect-borne diseases," said UTMB professor Scott Weaver, senior author of this paper. Chikungunya is a mosquito-borne virus that causes a disease characterized by fever and

Antibody Combination Puts HIV on The Ropes

Now a study using antibodies from one of these elite controllers has shown that a combination of three such antibodies can completely suppress the virus in HIV-infected mice. The findings, from the laboratory of Michel Nussenzweig, who is Zanvil A. Cohn and Ralph M. Steinman Professor at Rockefeller University and

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