But researchers have recently used T-cells engineered in the laboratory to combat tumours. Modified to include additional functions, these immune cells can hunt down and kill cancer cells. Unfortunately, however, such immune cell therapies can have significant side-effects. On top of that, the production of modified T-cells is technically challenging.
"Breast tumors are moving targets because they are really versatile," says Jun-Lin Guan, Francis Brunning Professor and Chair of the Department of Cancer at the University of Cincinnati College of Medicine and member of the Cincinnati Cancer Center and UC Cancer Institute, who co-authored the paper with postdoctoral fellow Syn
A study out this week in Nature, led by scientists from the University of Pennsylvania and The Wistar Institute, reveals why these relapses occur. While the combination therapies block off the principal pathway that cancer cells use to fuel their growth, the cells come to bypass this blockade and, like vehicles
The research found that altering the volume of a cell changed its internal dynamics, including the rigidness of the matrix lining the outer surface. In stem cells, removing water condenses the cell, influencing the stem cells to become stiff pre-bone cells, while adding water causes the cells to swell, forming
The research, published in Molecular Cell, builds on previous work by McGill professor Nahum Sonenberg, one of the senior authors of the new study. Cells in our body grow in size, mass and numbers through a process governed by a master regulator known as mTOR (Mechanistic Target of Rapamycin). Sonenberg discovered years
In new research, scientists at Washington University School of Medicine in St. Louis have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state. The technique makes it possible to study motor neurons of the human central nervous system in the lab. Unlike commonly
As the summer draws to a close, it's time to start putting away flip-flops, bathing suits and beach bags. But as the seasonal supplies disappear into the back of the closet, sunscreen should stay within arm's reach for year-round protection against the sun's ultraviolet rays. Because exposure to those harmful UV
A new study led by University of Pennsylvania and Technical University of Dresden scientists has identified an important regulator of this process, a protein called Del-1. Targeting it, the researchers noted, could be an effective way to improve stem cell transplants for both donors and recipients. There may also be