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New Drug Capsule May Allow Weekly HIV Treatment

The new capsule is designed so that patients can take it just once a week, and the drug will release gradually throughout the week. This type of delivery system could not only improve patients' adherence to their treatment schedule but also be used by people at risk of HIV exposure

New Structure of Key Protein Holds Clues for Better Drug Design

odies. In addition to Wthrich and Eddy, authors of the study, "Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2a Adenosine Receptor," were Tatiana Didenko and Pawel Stanczak of The Scripps Research Institute; Reto Horst of The Scripps Research Institute and Pfizer Worldwide Research and Development; Zhan-Guo Gao and

Bacteria Acquire Resistance From Competitors

The frequent and sometimes careless use of antibiotics leads to an increasingly rapid spread of resistance. Hospitals are a particular hot spot for this. Patients not only introduce a wide variety of pathogens, which may already be resistant but also, due to the use of antibiotics to combat infections, hospitals

Harnessing sperm to treat gynecological Diseases

Creating an effective way to target cancer cells with drugs is challenging on multiple fronts. For example, the drugs don't always travel deeply enough through tissues, and they can get diluted in body fluids or sidetracked and taken up by healthy organs. To get around these issues, scientists have turned

New Targets for Anti-Malaria Drugs

In the current study, researchers sought to uncover the role of plasmepsins IX and X, two of the 10 types of plasmepsin proteins produced by P. falciparum for metabolic and other processes. They created malaria parasites that lacked plasmepsin IX or X under experimental conditions and compared them to those that had

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