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New Targets for Anti-Malaria Drugs

In the current study, researchers sought to uncover the role of plasmepsins IX and X, two of the 10 types of plasmepsin proteins produced by P. falciparum for metabolic and other processes. They created malaria parasites that lacked plasmepsin IX or X under experimental conditions and compared them to those that had

Speedy Urine Test for Amphetamines Sends Results Via App

"Conventional drug detection generally use techniques that require long operation time, sophisticated experimental procedures, and expensive equipment with well-trained professional operators; moreover, they are not usually portable," says co-senior author Joon Hak Oh, who heads an organic electronics laboratory at Pohang University of Science and Technology (POSTECH). "Our method is

Melanoma Cells Rewire to Resist Drug Treatment

A study out this week in Nature, led by scientists from the University of Pennsylvania and The Wistar Institute, reveals why these relapses occur. While the combination therapies block off the principal pathway that cancer cells use to fuel their growth, the cells come to bypass this blockade and, like vehicles

Quick Test may Speed Antibiotic Treatment Combat Drug Resistance

Described in Scientific Reports, NIST's prototype sensor provides results in less than an hour, much faster than conventional antimicrobial tests, which typically require days to grow colonies of bacterial cells. Delayed results from conventional tests allow dangerous infections to progress before effective treatments can be found and provides a time window

Multifunctional Nano Sized Drug Carriers Based on Reactive Polypept(o)ides

In cooperation with researchers from the University of Tokyo and Gutenberg Research Awardee Prof. Kazunori Kataoka, Chemists from Mainz have been able to demonstrate that reactive polypept(o)ides constitute ideal building blocks to control morphology and function of carrier systems in a simple but precise manner. Polypept(o)ides (polysarcosine-block-polypeptide copolymers) have emerged

Producing Malaria Treatment at Large Scales

The first-choice treatment for malaria is artemisinin -- which is used in Chinese medicine to treat fever and inflammation as well as malaria. Before 2001, health care officials around the world administered the drug as a single compound, but this allowed malaria parasites to become drug-resistant. Scientists and medical professionals