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Cases of Unexplained Anaphylaxis Linked to Red Meat Allergy

As the researchers describe in their article published in Allergy, six of the 70 study participants evaluated for unexplained frequent anaphylaxis tested positive for an allergy to galactose-a-1,3-galactose, or alpha-gal, a sugar molecule found in beef, pork, lamb and other red meats. The six adult male participants all had IgE antibodies

New Molecule Shows Promise in HIV Vaccine Design

"An obstacle to creating an effective HIV vaccine is the difficulty of getting the immune system to generate antibodies against the sugar shield of multiple HIV strains," said Lai-Xi Wang, a professor of chemistry and biochemistry at UMD. "Our method addresses this problem by designing a vaccine component that mimics

Scientists Develop New Theory of Molecular Evolution

"Molecules are the basis of all life and we wanted to find out why molecules evolve the way they do," said study co-author David Pollock, PhD, professor of biochemistry and molecular genetics at the CU School of Medicine. Pollock and fellow author Richard Goldstein, Ph.D., professor of infection and immunity at

Cells Induce Inflammation Upon Detection of Cytoplasmic DNA

The presence of free DNA in the cytoplasm activates two distinct defense measures. The first is an antiviral immune response, mediated by induction of the synthesis and secretion of immunostimulatory messenger molecules called interferons. The second is a classical inflammatory reaction, which elicits symptoms such as fever, and localized swelling

Seemingly Acute Viral Infections Can Persist

New findings from the University of Pennsylvania suggest a mechanism that may explain how viruses can linger. Products of viral infection called defective viral genomes, DVGs for short, which have been known to be involved in triggering an immune response, can also kick off a molecular pathway that keeps infected

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