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Quick Test may Speed Antibiotic Treatment Combat Drug Resistance

Described in Scientific Reports, NIST's prototype sensor provides results in less than an hour, much faster than conventional antimicrobial tests, which typically require days to grow colonies of bacterial cells. Delayed results from conventional tests allow dangerous infections to progress before effective treatments can be found and provides a time window

Mitochondria Drive Cell Survival in Times of Need

The research, published in Molecular Cell, builds on previous work by McGill professor Nahum Sonenberg, one of the senior authors of the new study. Cells in our body grow in size, mass and numbers through a process governed by a master regulator known as mTOR (Mechanistic Target of Rapamycin). Sonenberg discovered years

Ricin only Lethal in Combination with Sugar

The plant toxin ricin is one of the most poisonous naturally occurring proteins, making it an extremely dangerous bioweapon. Ricin attacks have made the headlines a number of times over the years, including the spectacular "umbrella murder" in London in the 1970s, or more recently the ricin letters addressed to

Prototype Separates Components of Blood for Diagnostics

The system is optimized to sort out "exosomes," biological nanoparticles released from every type of cell in the body. Thought to play a large role in cell-to-cell communication and disease transmission, they have been objects of scientific curiosity since their discovery three decades ago. The miniscule size of exosomes, however, makes

Immune Cells Help Fat Deal With Environmental Challenges

The number of obese people as well as those suffering from type 2 diabetes is increasing worldwide. Both disorders are associated with metabolic changes including amplified inflammatory responses in adipose tissue. "Previous studies have indicated that immunosuppressive regulatory T-cells -- or Tregs for short -- play an important role in

A Tiny Device Offers Insights to How Cancer Spreads

What if there were a way to find those early aggressors? How are they different from the rest of the cells? And more importantly: Is there a way to stop them before they spread? These questions drove a team of researchers at the University of Michigan Comprehensive Cancer Center and Michigan

Motorized Molecules Drill Through Cells

Researchers at Rice, Durham (U.K.) and North Carolina State universities demonstrated in lab tests how rotors in single-molecule nanomachines can be activated by ultraviolet light to spin at 2 to 3 million rotations per second and open membranes in cells. The researchers used motors based on work by Nobel laureate Bernard

Chemo-Boosting Drug Discovered for Leukemia

In a study published in Cancer Cell, researchers at the Francis Crick Institute, King's College London and Barts Cancer Institute discovered that acute myeloid leukemia (AML) - the most common acute leukemia affecting adults - causes bone marrow to 'leak' blood, preventing chemotherapy from being delivered properly. Drugs that reversed bone

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