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Mitochondria Drive Cell Survival in Times of Need

The research, published in Molecular Cell, builds on previous work by McGill professor Nahum Sonenberg, one of the senior authors of the new study. Cells in our body grow in size, mass and numbers through a process governed by a master regulator known as mTOR (Mechanistic Target of Rapamycin). Sonenberg discovered years

Chemotherapy Pain Could be Eased by Jetlag Drug Study Suggests

The drug -- known as melatonin -- appeared to prevent pain caused by chemotherapy damage to nerves. It blocked harmful effects on nerve health, the study with rats shows. Experts say the findings help scientists understand more about ways to limit painful side effects of chemotherapy. Scientists from the Universities of Edinburgh

Chemo-Boosting Drug Discovered for Leukemia

In a study published in Cancer Cell, researchers at the Francis Crick Institute, King's College London and Barts Cancer Institute discovered that acute myeloid leukemia (AML) - the most common acute leukemia affecting adults - causes bone marrow to 'leak' blood, preventing chemotherapy from being delivered properly. Drugs that reversed bone

Fast Noninvasive Technique for Probing Cells may Reveal Disease

Determining the mechanical properties of cells may thus help doctors diagnose and track the progression of certain diseases. Current methods for doing this involve directly probing cells with expensive instruments, such as atomic force microscopes and optical tweezers, which make direct, invasive contact with the cells. Now MIT engineers have devised

Computer Models Provide New Understanding of Sickle cell Disease

Sickle cell disease affects hemoglobin, molecules within red blood cells responsible for transporting oxygen. In normal red blood cells, hemoglobin is dispersed evenly throughout the cell. In sickle red blood cells, mutated hemoglobin can polymerize when deprived of oxygen, assembling themselves into long polymer fibers that push against the membranes

Possible Treatment for Deadly Weight Loss

Doctors have known about this serious complication affecting cancer patients for a long time. The ancient Greeks called it cachexia, meaning "bad condition." Many cancer patients develop cachexia. An estimated 20 to 30 per cent of those with the condition may die of it and not from their tumors. For many of

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