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Unique Gene Therapy Prevents, Reverses Multiple Sclerosis in Animal Model

By combining a brain-protein gene and an existing medication, the researchers were able to prevent the mouse version of multiple sclerosis. Likewise, the treatments produced near-complete remission in the animal models. The findings, which researchers said have significant potential for treating multiple sclerosis and other autoimmune disorders, are published in

Ricin only Lethal in Combination with Sugar

The plant toxin ricin is one of the most poisonous naturally occurring proteins, making it an extremely dangerous bioweapon. Ricin attacks have made the headlines a number of times over the years, including the spectacular "umbrella murder" in London in the 1970s, or more recently the ricin letters addressed to

Nanocapsules Enable Cell-Inspired Metabolic Reactions

Metabolic processes inside living organisms involve a large variety of bio-molecules. These molecules are produced by specific enzymatic reactions. One example of such a bio-molecule is glucose-6-phosphate, a metabolite that is involved in important metabolic processes. It is central in the degradation of carbohydrates and can also be converted further

‘Missing Link’ Explains How Viruses Trigger Immunity

The research team demonstrated a protein called SIDT2 was crucial for cells to detect viral components in their environment, and initiate an immune response to reduce the virus' spread. As well as being an important part of the intricate 'arms race' between viruses and our immune system, the finding could inform

Immune Cells Help Fat Deal With Environmental Challenges

The number of obese people as well as those suffering from type 2 diabetes is increasing worldwide. Both disorders are associated with metabolic changes including amplified inflammatory responses in adipose tissue. "Previous studies have indicated that immunosuppressive regulatory T-cells -- or Tregs for short -- play an important role in

3-D-printed Biomaterials that Degrade on Demand

"It's a bit like Legos," said Ian Wong, an assistant professor in Brown's School of Engineering and co-author of the research. "We can attach polymers together to build 3-D structures, and then gently detach them again under biocompatible conditions." The research is published in the journal Lab on a Chip. The Brown team

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