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Inflammation Drives Progression of Alzheimer’s

Alzheimer's disease is a devastating neurodegenerative condition ultimately leading to dementia. An effective treatment does not yet exist. The disease is associated with the aberrant aggregation of small proteins called "Amyloid-beta" (Abeta) that accumulate in the brain and appear to harm neurons. In recent years, studies revealed that deposits of

Hunting for Immune Cells’ Cancer Targets

The screening technology, developed by Howard Hughes Medical Institute Investigator (HHMI) Christopher Garcia and colleagues after almost 20 years of basic molecular studies of the immune system, may ultimately lead to more effective immunotherapies, which harness the body's immune system to fight cancer. "This is going to widen the scope

New Methods Reveal the Biomechanics of Blood Clotting

The extensive results are published in two separate studies, in the Proceedings of the National Academy of Sciences (PNAS) and in Nature Methods. "We show conclusively that, in order to activate clotting, the cell needs a targeted force of a magnitude of just a few piconewtons -- or a force about a billion times

Fighting Myocardial Infarction with Nanoparticle Tandems

In a heart attack, clots usually lead to persistent circulatory problems in parts of the heart muscle, which then cause heart muscle cells to die. Attempts have been made for some time to revitalize the damaged heart tissue with replacement cells. "However, most of the cells are pushed out of

Engineering Non-immune Cells to Kill Cancer Cells

But researchers have recently used T-cells engineered in the laboratory to combat tumours. Modified to include additional functions, these immune cells can hunt down and kill cancer cells. Unfortunately, however, such immune cell therapies can have significant side-effects. On top of that, the production of modified T-cells is technically challenging.