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Brain Cells Die in Alzheimer’s and FTD

In the brain, LSD1 (lysine specific histone demethylase 1) maintains silence among genes that are supposed to be turned off. When the researchers engineered mice that have the LSD1 gene snipped out in adulthood, the mice became cognitively impaired and paralyzed. Plenty of neurons were dying in the brains of

Nerve Cells Gatekeepers Take Many Forms

Using sophisticated imaging and statistical methods, the scientists employed single-molecule FRET imaging techniques to establish a beachhead at the NMDA receptor gate that, when activated, allows ions to flow through the nerve cell's membrane. FRET stands for Förster resonance energy transfer. It is a way to use the light emitted by

Unique Gene Therapy Prevents, Reverses Multiple Sclerosis in Animal Model

By combining a brain-protein gene and an existing medication, the researchers were able to prevent the mouse version of multiple sclerosis. Likewise, the treatments produced near-complete remission in the animal models. The findings, which researchers said have significant potential for treating multiple sclerosis and other autoimmune disorders, are published in

The Brain’s Rejuvenating Cells

The brain is a fragile and unique organ that has its own specially tailored immune system, separate from the rest of the body. The primary role of the brain's immune cells, called microglia, is to recognize, disassemble, and dispose of various substances that do not function properly in the brain,

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