In the brain, LSD1 (lysine specific histone demethylase 1) maintains silence among genes that are supposed to be turned off. When the researchers engineered mice that have the LSD1 gene snipped out in adulthood, the mice became cognitively impaired and paralyzed. Plenty of neurons were dying in the brains of
Using sophisticated imaging and statistical methods, the scientists employed single-molecule FRET imaging techniques to establish a beachhead at the NMDA receptor gate that, when activated, allows ions to flow through the nerve cell's membrane. FRET stands for Förster resonance energy transfer. It is a way to use the light emitted by
"Every year, thousands of people across the country die from the flu or its complications -- despite widespread use of annual influenza vaccines," said Daniel J. Prantner, PhD, a research associate in the Department of Microbiology and Immunology at the University of Maryland School of Medicine (UM SOM). "In the
By combining a brain-protein gene and an existing medication, the researchers were able to prevent the mouse version of multiple sclerosis. Likewise, the treatments produced near-complete remission in the animal models. The findings, which researchers said have significant potential for treating multiple sclerosis and other autoimmune disorders, are published in
The disorder can therefore lead to serious brain damage and even death in the worst cases. A team at the University of Geneva (UNIGE), Switzerland, supported by the Swiss National Science Foundation (SNSF) has succeeded in precisely describing the effects of a frequent genetic mutation in cases of congenital hyperinsulinism.
This is the finding of a study led by researchers from NYU School of Medicine and published online August 29 in Scientific Reports. The new study is based on decades of work arguing that the contribution to disease of key proteins -- amyloid beta and tau in Alzheimer's, alpha-synuclein in Parkinson's, and
Now, a new study in mice shows that females vaccinated before pregnancy and infected with Zika virus while pregnant bear pups who show no trace of the virus. The findings offer the first evidence that an effective vaccine administered prior to pregnancy can protect vulnerable fetuses from Zika infection and
ALS, also known as Lou Gehrig's disease, is a lethal, progressive neurodegenerative disorder that affects the motor nerve cells in both the brain and the spinal cord. The progressive degeneration of motor neurons leads to atrophy, paralysis and eventually death due to failure of the respiratory muscles. Since the exact cause