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New Findings to Help HIV Scientists Establish ‘Template’ for Potent antibodies

"Uncovering the process by which neutralizing antibodies develop is critical to HIV vaccine design," said Elise Landais, Senior Research Scientist with IAVI and lead author of the study. "A small fraction of people living with HIV can naturally produce exceptionally powerful and broad antibodies that could prevent HIV from infecting

In the Fight Against Viral Infection, Spelling Counts

Now, scientists have found that a key similarity between our genes and those of many viruses -- a way of spelling out the genetic code -- has likely allowed viruses to evade our cellular defenses. Paul Bieniasz, a Rockefeller professor and Howard Hughes Medical Institute Investigator who led the work,

New Molecule Shows Promise in HIV Vaccine Design

"An obstacle to creating an effective HIV vaccine is the difficulty of getting the immune system to generate antibodies against the sugar shield of multiple HIV strains," said Lai-Xi Wang, a professor of chemistry and biochemistry at UMD. "Our method addresses this problem by designing a vaccine component that mimics

New Targets for Anti-Malaria Drugs

In the current study, researchers sought to uncover the role of plasmepsins IX and X, two of the 10 types of plasmepsin proteins produced by P. falciparum for metabolic and other processes. They created malaria parasites that lacked plasmepsin IX or X under experimental conditions and compared them to those that had

Seemingly Acute Viral Infections Can Persist

New findings from the University of Pennsylvania suggest a mechanism that may explain how viruses can linger. Products of viral infection called defective viral genomes, DVGs for short, which have been known to be involved in triggering an immune response, can also kick off a molecular pathway that keeps infected

Speedy Urine Test for Amphetamines Sends Results Via App

"Conventional drug detection generally use techniques that require long operation time, sophisticated experimental procedures, and expensive equipment with well-trained professional operators; moreover, they are not usually portable," says co-senior author Joon Hak Oh, who heads an organic electronics laboratory at Pohang University of Science and Technology (POSTECH). "Our method is

PET imaging tracks Zika virus infection, disease progression in mouse model

Small-animal imaging has become an important research tool for preclinical studies of infectious diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). "Traditional methods of infectious disease research using animal models have provided limited information about disease progression until the

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