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Inflammation Drives Progression of Alzheimer’s

Alzheimer's disease is a devastating neurodegenerative condition ultimately leading to dementia. An effective treatment does not yet exist. The disease is associated with the aberrant aggregation of small proteins called "Amyloid-beta" (Abeta) that accumulate in the brain and appear to harm neurons. In recent years, studies revealed that deposits of

New Term for Role of Microbiota in Neurodegeneration Proposed

University of Louisville neurology professor Robert P. Friedland, M.D., and Matthew R. Chapman, Ph.D., professor at the University of Michigan, have proposed a new term to describe an interaction between gut microbiota and the brain in an article released today in PLOS Pathogens. Friedland and Chapman propose the term "mapranosis" for the

No Evidence that Gadolinium Causes Neurologic Harm

Gadolinium-based contrast media were introduced in 1988 as a means of enhancing MRI images and are commonly used today. The contrast agent is injected into the patient's bloodstream and eliminated from the body through the kidneys. "It's estimated that approximately 400 million doses of gadolinium have been administered since 1988," said

Smart People Have Better Connected Brains

Understanding the foundations of human thought is fascinating for scientists and laypersons alike. Differences in cognitive abilities -- and the resulting differences for example in academic success and professional careers -- are attributed to a considerable degree to individual differences in intelligence. A study just published in Scientific Reports shows that these

Immune Cells Help Rebuild Damaged Nerves

"This finding is quite surprising and raises an important question: do neutrophils play a significant role in nerve disorders?" said Richard Zigmond, PhD, senior author on the study and professor of neurosciences, neurosurgery, and pathology at Case Western Reserve University School of Medicine. Neutrophils are one of the most common

Brain Cells Die in Alzheimer’s and FTD

In the brain, LSD1 (lysine specific histone demethylase 1) maintains silence among genes that are supposed to be turned off. When the researchers engineered mice that have the LSD1 gene snipped out in adulthood, the mice became cognitively impaired and paralyzed. Plenty of neurons were dying in the brains of

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