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Designer Nanoparticles Destroy a Broad Array of Viruses

Now, an international group of researchers including UIC professor of chemistry Petr Kral, have designed new anti-viral nanoparticles that bind to a range of viruses, including herpes simplex virus, human papillomavirus, respiratory syncytial virus and Dengue and Lentiviruses. Unlike other broad-spectrum antivirals, which simply prevent viruses from infecting cells, the

Cells Induce Inflammation Upon Detection of Cytoplasmic DNA

The presence of free DNA in the cytoplasm activates two distinct defense measures. The first is an antiviral immune response, mediated by induction of the synthesis and secretion of immunostimulatory messenger molecules called interferons. The second is a classical inflammatory reaction, which elicits symptoms such as fever, and localized swelling

A Tubular Structure to Stop Cell Growth

Some of the treasures of Easter Island are invisible. In the 1960s, researchers discovered a bacterium that produces a compound with potent anti-fungal properties. They called it rapamycin, from the island's native name Rapa Nui. Although evolutionarily distant, fungi and mammals share much of the basic biochemistry that drives cellular

Genes are Controlled by Nano Footballs Scientists Discover

By placing tiny glowing probes on transcription factors -- special chemicals inside cells which control whether a gene is switched 'on' or 'off' -- researchers gained a remarkable new insight into the way in which genes are controlled. Crucially, they discovered that transcription factors operate not as single molecules as was

‘Missing Link’ Explains How Viruses Trigger Immunity

The research team demonstrated a protein called SIDT2 was crucial for cells to detect viral components in their environment, and initiate an immune response to reduce the virus' spread. As well as being an important part of the intricate 'arms race' between viruses and our immune system, the finding could inform

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