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Alcohol Damages DNA and Increases Cancer Risk

Much previous research looking at the precise ways in which alcohol causes cancer has been done in cell cultures. But in this study, researchers have used mice to show how alcohol exposure leads to permanent genetic damage. Scientists at the MRC Laboratory of Molecular Biology, Cambridge, gave diluted alcohol, chemically known

New Structure of Key Protein Holds Clues for Better Drug Design

odies. In addition to Wthrich and Eddy, authors of the study, "Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2a Adenosine Receptor," were Tatiana Didenko and Pawel Stanczak of The Scripps Research Institute; Reto Horst of The Scripps Research Institute and Pfizer Worldwide Research and Development; Zhan-Guo Gao and

Harnessing sperm to treat gynecological Diseases

Creating an effective way to target cancer cells with drugs is challenging on multiple fronts. For example, the drugs don't always travel deeply enough through tissues, and they can get diluted in body fluids or sidetracked and taken up by healthy organs. To get around these issues, scientists have turned

Hunting for Immune Cells’ Cancer Targets

The screening technology, developed by Howard Hughes Medical Institute Investigator (HHMI) Christopher Garcia and colleagues after almost 20 years of basic molecular studies of the immune system, may ultimately lead to more effective immunotherapies, which harness the body's immune system to fight cancer. "This is going to widen the scope