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New Genetic Syndrome Predisposes the Body to Cancer

A research led by Jordi Surrallés, professor of the Department of Genetics and Microbiology at the Universitat Autònoma de Barcelona, director of the Genetics Unit at the Hospital de la Santa Creu i Sant Pau and lead researcher at the Centre for Biomedical Network Research on Rare Diseases (CIBERER), has

Stimuli Fading Away en Route to Consciousness

The researchers are basing their study on a well-known phenomenon: When presented with two images in rapid succession, humans can only consciously perceive the second one if there is sufficient time between the two presentations. In this study the participants saw a series of pictures on a computer screen, where

Mitochondria Drive Cell Survival in Times of Need

The research, published in Molecular Cell, builds on previous work by McGill professor Nahum Sonenberg, one of the senior authors of the new study. Cells in our body grow in size, mass and numbers through a process governed by a master regulator known as mTOR (Mechanistic Target of Rapamycin). Sonenberg discovered years

Unique Gene Therapy Prevents, Reverses Multiple Sclerosis in Animal Model

By combining a brain-protein gene and an existing medication, the researchers were able to prevent the mouse version of multiple sclerosis. Likewise, the treatments produced near-complete remission in the animal models. The findings, which researchers said have significant potential for treating multiple sclerosis and other autoimmune disorders, are published in

Immune cells produce wound healing factor, could lead to new IBD treatment

The research team, led by Georgia State University and the University of Michigan, wanted to understand how a wound heals in the intestine because in IBD, which includes Crohn's disease and ulcerative colitis, damage to the intestinal epithelial barrier allows bacteria in the intestine to go across the barrier and

PET imaging tracks Zika virus infection, disease progression in mouse model

Small-animal imaging has become an important research tool for preclinical studies of infectious diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). "Traditional methods of infectious disease research using animal models have provided limited information about disease progression until the

Researchers Identify New Target Develop new Drug for Cancer therapies

The target is an enzyme called PPT1, which controls both the mechanistic target of rapamycin (mTOR), a major regulator of growth in cancer cells, as well as a process called autophagy, a built-in resistance mechanism which allows cells to survive when under attack by breaking down unneeded parts and recycling

Congenital Hyperinsulinism A Serious Yet Poorly Understood Condition

The disorder can therefore lead to serious brain damage and even death in the worst cases. A team at the University of Geneva (UNIGE), Switzerland, supported by the Swiss National Science Foundation (SNSF) has succeeded in precisely describing the effects of a frequent genetic mutation in cases of congenital hyperinsulinism.

Ricin only Lethal in Combination with Sugar

The plant toxin ricin is one of the most poisonous naturally occurring proteins, making it an extremely dangerous bioweapon. Ricin attacks have made the headlines a number of times over the years, including the spectacular "umbrella murder" in London in the 1970s, or more recently the ricin letters addressed to

Nanocapsules Enable Cell-Inspired Metabolic Reactions

Metabolic processes inside living organisms involve a large variety of bio-molecules. These molecules are produced by specific enzymatic reactions. One example of such a bio-molecule is glucose-6-phosphate, a metabolite that is involved in important metabolic processes. It is central in the degradation of carbohydrates and can also be converted further

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